Professor Yildirim is an applied mathematician whose research is on mathematical modeling of biological systems with a focus on regulatory biochemical networks. Although many intracellular regulatory networks have been extensively studied using advanced experimental techniques, it has turned out to be quite difficult to make predictions about how individual components are assembled and dynamically regulated, and how the behavior of metabolism as a whole are related with the properties of the individual parts. Dr Yildirim is interested in development of quantitative mathematical models that are comparable with experimental data to address such questions.

Before coming to New College, Professor Yildirim held postdoctoral positions at UNC-Chapel Hill and McGill University. 

Linear Algebra     
Mathematical Modeling I
Differential Equations
Advanced Linear Algebra

Yildirim N., Violin JD., DiPilato LM., Elston TC., Zhang J. and Lefkowitz RJ. (2008), b2-adrenergic receptor signaling and desensitization elucidated by quantitative modeling of real-time cAMP dynamics, Journal of Biological Chemistry,283(5), 2949-2961.

Hao N., Yildirim N., Parnell S., Errede B., Elston T.C., Dohlman H.G. (2007), Modeling signal specificity by feedback inhibition, FASEB Journal, 21 (5), A264-A264.

Yildirim, N.(2006) Use of symbolic and numeric computation techniques in analysis of biochemical reaction networks, International Journal of Quantum Chemistry, 106,256-265.

Yildirim, N., Santillan, M., Horike, D., and Mackey, M. C. (2004) Dynamics and bistability in a reduced model of the lac operon, Chaos, 14(2), 279-292.

Mackey, M.C., Santillan, M. and Yildirim, N. (2004) Modeling operon dynamics: The tryptophan and lactose operons as paradigms, Comptes Rendus Biologies, 327(3), 211-224.

Yildirim, N., Hao, N., Dohlman, H.G. and Elston, T.C. (2004) Mathematical Modeling of RGS and G Protein Regulation in Yeast, Methods in Enzymology, v.389, 383-398, Academic Press, New York.

Subasi, M., Yildirim, N. and Yildiz, B. (2004) An improvement on Fibonacci search method in optimization theory, Applied Mathematics and Computation, 147(3), 893-901.

Hao, N., Yildirim, N., Wang, Y.Q., Elston, T.C. and Dohlman, H.G.(2003) Regulators of G protein signaling and transient activation of signaling: Experimental and computation analysis reveals negative and positive feedback controls on G protein activity, Journal of Biological Chemistry, 278(47), 46506-46515.

Yildirim, N. and Mackey, M.C.(2003) Feedback regulation in the lactose operon: A mathematical modeling study and comparison with experimental data, Biophysical Journal, 84(5), 2841-2851.

Yildirim, N., Akcay, F., Okur, H. and Yildirim, D. (2003) Parameter estimation of nonlinear models in biochemistry: A comparative study on optimization methods, Applied Mathematics and Computation, 140(1), 29-36.

Yildirim, N., Ciftci, M. and Kufrevioglu, O.I. (2002) Kinetic analyses of multi enzyme systems: A case study of creatine kinase- hexokinase and glucose 6-phosphate dehydrogenase, Journal of Mathematical Chemistry, 31(1), 121-130.

Bayram, M., Simsek, H. and Yildirim, N. (2002) Automatic calculation of Alexander polynomials of (3,k)-torus knots, Applied Mathematics and Computation, 136(2-3), 505-510.3

Professor Yildirim's research focuses on mathematical modeling of biological systems with an emphasis on regulatory biochemical networks